Nearly 1 in 4 U.S. hospitalized patients experience harmful events, study finds 

Experts say U.S. hospitals still have a long way to go to improve patient safety.

Jan. 11, 2023, 5:02 PM EST / Updated Jan. 11, 2023, 9:32 PM EST

By Kaitlin Sullivan

Nearly 1 in 4 patients who are admitted to hospitals in the U.S. will experience harm, according to a study published Wednesday in the New England Journal of Medicine

The stark findings underscore that, despite decades of effort, U.S. hospitals still have a long way to go to improve patient safety, experts say.

“These numbers are disappointing, but not shocking,” said lead study author Dr. David Bates, the chief of general medicine at Brigham and Women’s Hospital and the medical director of clinical and quality analysis for Mass General Brigham in Boston. “They do show we still have lots of work to do.”

The research looked at the medical records of 2,809 patients who were hospitalized in 11 Boston-area hospitals in 2018. The study excluded people who were admitted for observation only or for hospice, rehabilitation, addiction treatment or psychiatric care. 

Hospital data showed that 663 of the patients — about 24% — experienced at least one event during their stays that negatively affected their health, even temporarily.  

A total of 222 adverse events were considered preventable, meaning errors resulted in patient harm. That translates to about 7% of the total admissions the researchers analyzed. Twenty-nine people, or 1% of the total of those admitted, experienced serious preventable adverse events that resulted in serious harm. One death was considered preventable. 

The majority of the bad outcomes, however, were deemed unpreventable. They can include known side effects from certain medications or known risks associated with surgery.

The most common adverse events overall (nearly 40%) were related to medications given in the hospital. Surgery and other procedures accounted for just over 30%, followed by what the study authors called “patient-care events,” at 15%. They include falls and bedsores, both of which are considered preventable. 

One bright spot, experts said, was that infections acquired in the hospital accounted for only about 12% of the adverse events — a significant decrease from a 1991 study that found infections were the second-most-common adverse event.

The 1991 study, called the Harvard Medical Practice Study I, is considered landmark research. Using data from patients hospitalized in New York state in 1984, it found that only about 4% of hospitalized patients experienced harm. However, the study looked for a smaller range of adverse events than the current research, and hospitals have become much better at reporting harm when it does occur. 

“It’s clear that, at least, the rate is not going down and that harm continues to be a really serious issue,” Bates said. 

Dr. Albert Wu, the director of the Center for Health Services and Research Outcomes at the Johns Hopkins Bloomberg School of Public Health, said in an email that while progress has been made in some areas, new risks have emerged as medicine has advanced.

“Although we have eliminated some causes of harm, there are new kinds of harm that have been created, associated with potent new medications and new procedures,” said Wu, who wasn’t involved with the new research.

For example, drug companies have made significant advances over the three decades since the last report was published, but with an abundance of available drugs comes more opportunity for medication-related errors.

“There are many more medications available today compared to 1991, and some of the medicines have a smaller therapeutic margin, which is the gap between the therapeutic effect and dangerous dose,” said Dr. Donald Berwick, the president emeritus and a senior fellow at the Institute for Healthcare Improvement in Boston. Berwick wrote an editorial that was published Wednesday alongside the new study.

Even the technologies implemented to prevent medication errors can create new opportunities for mishaps.

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